apalutamide will lower the extent or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicines which might be CYP3A4 substrates may end up in decreased publicity to those prescription drugs.Allergic reactions including rash, ang
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